Introduction
In Part 1, we explored the current thinking of conventional medicine’s’ approach to cancer, how it’s treated pharmaceutic ally using dangerous poisonous substances or simply just to cut or burn it out of the body. These somewhat primitive treatments mimic the bloodletting and mercury treatments that lasted 2000 years until the late 19th century. Medicine uses these types of practice when they don’t understand the disease, despite the fact that the answers to cancer are hidden in the research. Do you honestly believe that this is a highly intelligent organism like the human body would not have an answer to cancer. God is love not cruel.
The Origins of Chemotherapy
After World War I, there was a stockpile of nitrogen mustard gas that was used as a weapon to kill the fighting armies during the conflict. During World War II, although the gas was not used, the Department of Defence (DOD) thought about how and where this surplus mustard gas could be used. Then, in 1945 in an experimental research facility, some army personnel were exposed to this gas and died. When they were autopsied the pathologist noticed that their white blood count had decreased and the bone marrow had been suppressed. As a result one of the Department Of Defence (DOD) doctors had an idea, that maybe the nitrogen gas could be used
to treat lymphoma and leukemia since they were both cancers derived from the bone marrow (the white cell line).
The DOD contracted 2 Yale University scientists, Louis Goodman and Alfred Gilman and asked them to conduct a study with animals who had cancerous growths, using a synthesized drug containing a nitrogen mustard gas derivative, which they did, and confirmed that the bone marrow had been ‘wiped out’ and the tumors regressed. They then decided in 1946 to experiment with a human cancer patient suffering from advanced lymphoma of which there was no cure. It worked and the patient’s tumors also regressed, although within 6 weeks he was dead. Despite the excitement that finally they had found an answer to cancer using in the 60’s MOPP (Mustargen Oncovin Procarbazine Prednisone) an acronym for the 4 drug regimen treatment put together by a Dr. Vincent Devita to treat Hodgkin’s lymphoma not curing it but extending the patients life, whose quality is affected by the chemotherapy with constant bouts of weakness and no energy. In most if not all cases, some of the cancer cells (the stem cells) are resistant to the toxic drugs and the cancer returns and a lot of the time more aggressively.
Routinely, these toxic drugs like Methotrexate affect the heart and liver. Avastin, interferes with bleeding which could be fatal. Even today, patients with blood derived cancers die because of the use of immunosuppressant drugs that shut down the immune system leaving the patient defenseless.
Radiation
Due to the work Madame Curie (1867-1934), physicist and chemist, who introduced Radiation as a regimen to burn cancer out of the human body In and around 1896, 2 physicians in France and Chicago began using X-rays to treat cancer. Victor Despeignes used them on a patient with stomach cancer, but the results were inconclusive since the patient was receiving other treatments, but of course the patient died (not a big surprise). The second physician, Emil Grubbe from Chicago used x-rays to treat breast cancer. Grubbe himself must have been a strong individual since he himself had 90 operations for recurrent cancer from the exposure to
radiation, which he ultimately died from, but not before infecting..excuse me..instructing 7000 physicians on the medical use of x-rays.
Radium was now becoming popular, and it was at this point society ‘lost it’; manufacturers were putting radium in toothpaste, water dispensers, irradiated baths, radon inhalation rooms and radiation spas. Then people started dying in 1915 and people were developing carcinomas (another surprise). In the early days, Curie’s experimental materials included Pitchblende (a radioactive uranium rich mineral), Torbenite (a radioactive hydrated green copper uranium phosphate mineral) and Thorium (a radioactive actinide metal) carrying out her experiments in an badly ventilated, non waterproof shed that was converted from a schools dissection room, unaware of the induced damage she was being subjected to. Madame Curie and her husband Pierre also both walked around with uranium in their pockets and they received a Nobel prize alongside Becquerel in Physics in 1903. By 1934 she would be dead at the age of 66 from aplastic anemia contracted from the long term exposure of radiation (this is a testimonial to the wonderful human body that kept her alive so long after so much toxic poisoning she endured and her ignorance of how toxic radiation is, went with her to her grave ).
The Origin of Cancer
Now that we have discussed the last 100 years of the modern ‘dark ages’ let us now ‘enter the light’. Before I do, and please bear with me because it’s relevant, I would like to explain early human reproduction, specifically the early development of the placenta.
Between 5-6 days after fertilization the original tiny ball of some 12-16 cells develop into an initial embryo referred to as a ‘Blastocyst’. This consists of a single layer of outer cells called ‘Trophoblast‘ cells, that are designed to invade the Endometrium of the Uterus, destined to be the Placenta, while the inner cells develop into the Embryo body. In preparation of the uterine invasion, the trophoblast cells secrete enzymes to digest part of the ‘Zona Pellucida‘, the outer glycoprotein coating of the ‘Ovum’ or egg cell as a precursor activity before uterine implantation. The uterus can only accept implantation between day 20 and 24 of the ovulatory
cycle. Cells within the endometrium secrete nutritive substances in preparation for implantation and cell surface receptors called ‘Integrins’ begin to grow and will act as ‘docking sites’ for the trophoblast cell complex.
Once the blastocyst makes contact with the uterus it is essential that it attaches to the endometrial epithelium quickly, to survive. Once contact is established, the outer trophoblast layer of cells known as the Syncytiotrophoblast secrete more enzymes to break down the endometrial extracellular matrix preparing for blastocyst implantation. Within 7-8 days the blastocyst has advanced further into the endometrium and signaling (autocrine) molecules secrete hormones such as Hormone Chorionic Gonadotropin (hCG). When hCG is released into the bloodstream, it stimulates the ovaries to release estrogen and progesterone that stimulate growth essential for implantation), and ‘Insulin-like Growth Factor’(IGF) allowing further invasive advancement.
To initiate this 2 way communication the trophoblast synthesizes various growth factor signaling that includes Leukemia Inhibitory Factor ( LIF ), an Interleukin 6 cytokine cell signaling substance that influences uterine acceptance, Decidualization ( endometrium cell conversion for pregnancy purposes ), blastocyst invasion and development, and immune modulation, Colony Stimulating factor I ( Glycoprotein used for intracellular signaling pathway for cell proliferation and differentiation and various other transcription factors.
In order to secure the survival of the fetus the early placenta mass the Trophoblast secretes a number of immune modulating signals like Interleukin 10 which down regulates the expression of TH1, MHC antigens, stimulatory molecules from macrophages and blocks NF-kB ( Nuclear factor Kappa B which is a protein complex that regulates an inflammatory response ). In addition the Trophoblast also produces an enzyme that degrades ‘tryptophan’ that is essential for T-cell mobilization thus paralyzing their activity. (I know what you are thinking..’ain’t the body smart).
Isn’t this an article about Cancer?
Yes, but the signaling and the overall characteristics of the early placenta, the trophoblast, are identical to CANCER. This was discovered in 1900 by a brilliant embryologist named Dr John Beard and has subsequently been confirmed in our modern times by Dr. C. Ferretti in the October 2006 issue of Human Reproduction Update, where he states that:
“Both cancer and trophoblast cells share the same molecular circuitry for their proliferative, invasive and migratory capacities.”
In addition the extraordinary work of Drs Michael J Murray and Bruce A Lessey both from the department of Obstetrics and Gynecology University of North Carolina and their 1999 publication entitled ‘Embryo Implantation and Tumor metastasis: Common Pathways of invasion and Angiogenesis’ present the biology of the trophoblast to the metastatic potential of cancer. In conclusion If the trophoblast is indeed cancer that means that every pregnant woman has cancer, so how does the body get rid of the malignancy?
The trophoblast is a result of fertilization of an egg from donated sperm from the male species but cancer can ignite in both male and female without fertilization, how can that be?
How does cancer occur and where does it stem from?
In part 3 all these questions will be answered and the discovery of the origins of cancer over a 100 years ago that was conveniently forgotten.
References/Acknowledgments
1. Bicentennial Voices : The Birth of Chemotherapy ( Yale school of medicine website )
2. Madame Curie/History of Radiation Wikipeadia
3. Pinopod/Blastocyst/HCG/Zona Pellucida/Syncytiotrophoblast/Chorionic Villi Wikipeadia
4. Leukemia Inhibiting factor: roles in embryo implantation and in non hormonal contraception (Scientific World Journal Vol 2014, Article ID 201514 N.Salleh, N.Ginbabu
5. Transforming growth factor alph,beta/Platelet derived growth factor/insulin like growth factor/Colony Stimulating factor 1/Interleukin 1,6.10/NF-KB Wikipeadia
6. The Trophoblast and the Origins of cancer ( 2009) Nicholas Gonzalez MD,Linda Isaacs MD
Footnote:
My intentions in writing these articles is not to enforce an opinion but simply to present
the facts that exist and have existed in history so you can make a judgement or form an
opinion.
My only caveat is that I believe that the human organism is so incredibly complex and
remarkably intelligent that its creation/evolution is from a divine power,whose intention
was to simply keep the body alive with the correct fuel, and if it ran into trouble, be fixed
by substances found in nature.
If the body became damaged structurally,chemically or mentally, us humans could
acquire the knowledge to repair it using means that work with the body, not against the
body.
A truth that was upheld by Hippocrates and a truth upheld by Naturopathic physicians.
Author : Eric Malouin , AMCC’s student
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