Endometriosis is now recognized as a chronic inflammatory and hormone-dependent condition involving complex interactions between the immune system, hormonal balance, gut microbiota, and oxidative stress. Recent research increasingly highlights the value of an integrative approach focused on terrain modulation.

Inflammation, microbiota and the gut–uterus axis

Emerging data show a central role of the gut microbiota in endometriosis pathophysiology. Dysbiosis may influence systemic inflammation, intestinal permeability, and estrogen metabolism, contributing to symptom progression.
The gut–brain–immune axis is also increasingly seen as a key pathway in chronic pain modulation.

Evidence-based anti-inflammatory nutrition

Recent studies support the role of an anti-inflammatory diet in the complementary management of endometriosis.

Key findings include:

• Reducing inflammatory load: lowering added sugars and ultra-processed foods is associated with reduced systemic inflammatory markers
• Glycemic stability: balanced meals help limit glucose fluctuations that may promote inflammation
• Omega-3 vs omega-6 balance: omega-3 fatty acids support anti-inflammatory pathways, while excess omega-6 may sustain inflammation

Micronutrition and hormonal regulation

• Vitamin D: deficiency is linked to increased symptom severity and immune dysregulation
• Dietary fiber: supports estrogen elimination through intestinal transit and bile excretion
• Antioxidants: polyphenol-rich foods help reduce oxidative stress, a key driver of chronic inflammation

Digestive system and immunity: a key axis

Endometriosis is frequently associated with digestive disorders such as IBS, reinforcing the hypothesis of a global immune-inflammatory link. Gut health therefore appears central, involving microbiota modulation, fiber intake, and anti-inflammatory dietary strategies.

Integrative perspectives in natural health

Current data suggest the most promising approaches combine:

• gut microbiota modulation
• reduction of systemic inflammation
• omega-3 fatty acid balance
• vitamin D and micronutrient optimization
• glycemic control
• hormonal metabolism support

These strategies do not replace medical treatment but are part of an integrative, terrain-based approach increasingly supported by scientific literature.